Ria Ramadhani Dwi Atmaja; Fidia Rizkiah Inayatilah; Mawar Yuli Muktisari; Safa'atun Ni'mah; Imam Subandi
Abstract
The plant known as Red fruit oil (Pandanus conoideus Lamk.) has the ability to accelerate wound healing. Red fruit oil contains compounds that are active in the healing process of incisional ...
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The plant known as Red fruit oil (Pandanus conoideus Lamk.) has the ability to accelerate wound healing. Red fruit oil contains compounds that are active in the healing process of incisional wounds, including tocopherols, carotenoids, oleic acid, linoleic acid, and linolenic acid. To enhance stability and penetration, red fruit oil was formulated in an emulsion form in this research. The aim of this study was to determine the activity of red fruit oil emulgel on collagen density and the amount of angiogenesis in incisional wound healing and to determine the optimal dose of red fruit oil emulgel on collagen density and the amount of angiogenesis in incisional wound healing. This research is a true experimental study that employs a post-test-only control group design with 6 treatment groups. ImageJ software is used to measure the percentage of collagen density area, while image raster software is used to measure angiogenesis. This study has shown that red fruit oil emulgel can enhance collagen production and angiogenesis in incisional wound healing. The optimal dose concentration of red fruit oil emulgel to increase collagen density and the amount of angiogenesis in incisional wound healing was shown in red fruit oil emulgel with a concentration of 15% w/v. The conclusion is that red fruit oil emulgel leads to an increase in collagen density and angiogenesis during wound healing in rat incisions.
